Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | PDE4A | P27815 | 5/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21190866 | 0.88 | IKBKE (0.46) | SYKHTTPDE4DPDE4APDE4B | |
| SCHEMBL21190898 | 0.84 | CSNK2A1 (0.48) | PDE4BCSNK2A1 | |
| SCHEMBL21191018 | 0.83 | SYK (0.42) | SYKHTTPDE4DPDE4APDE4B | |
| SCHEMBL21191020 | 0.81 | BRD4 (0.52) | SYKHTTPDE4DPDE4APDE4B | |
| SCHEMBL21190904 | 0.81 | BRD4 (0.37) | CSNK2A1UTS2RBRD4 | |
| SCHEMBL21190862 | 0.80 | BRD4 (0.43) | SYKHTTPDE4DPDE4APDE4B | |
| SCHEMBL20789797 | 0.78 | PDE4D (0.46) | HTTPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20789795 | 0.78 | PDE4D (0.46) | HTTPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL24252789 | 0.78 | SYK (0.44) | SYKPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL21191007 | 0.78 | SYK (0.44) | SYKPDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741758-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |
| US-9359548-B2 | Organic electroluminescent device | UDC IRELAND LIMITED (IE) | 2016-06-07 | — | — | US | disclosed |