Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.52 |
| ▸ | THRA | P10827 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21191040 | 0.88 | BRD4 (0.54) | BRD4LRRK2 | |
| SCHEMBL21191174 | 0.80 | CDK2 (0.47) | BRD4POLBCDK2KDRLRRK2 | |
| SCHEMBL21191076 | 0.79 | BRD4 (0.51) | BRD4THRATHRBSCN9A | |
| SCHEMBL21190875 | 0.77 | BRD4 (0.49) | BRD4CDK2KDRPTGS2PDE4A | |
| SCHEMBL21191028 | 0.77 | BRD4 (0.52) | BRD4CDK2KDRPTGS2PDE4A | |
| SCHEMBL21190894 | 0.76 | BRD4 (0.51) | BRD4THRATHRBPOLBPTGS2 | |
| SCHEMBL21191152 | 0.75 | BRD4 (0.56) | BRD4POLBIKBKBSCN9A | |
| SCHEMBL21191038 | 0.74 | BRD4 (0.42) | BRD4THRATHRBPOLBCDK2 | |
| SCHEMBL16334753 | 0.73 | OPRK1 (0.43) | THRATHRBPOLBLRRK2 | |
| SCHEMBL21191124 | 0.73 | SCN9A (0.46) | BRD4POLBSCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |
| US-9359548-B2 | Organic electroluminescent device | UDC IRELAND LIMITED (IE) | 2016-06-07 | — | — | US | disclosed |