Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | PARG | Q86W56 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498627 | 0.87 | KMT2A (0.51) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL19994876 | 0.87 | KMT2A (0.51) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL20988223 | 0.84 | KMT2A (0.56) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1369496 | 0.81 | LMNA (0.53) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL20779633 | 0.81 | CA1 (0.50) | KMT2ASMN1; SMN2LMNAALDH1A1IDO1 | |
| SCHEMBL3087579 | 0.80 | CA1 (0.58) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18077979 | 0.80 | ALDH1A1 (0.54) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL957480 | 0.78 | MEN1 (0.53) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL24429355 | 0.78 | SMN1; SMN2 (0.60) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3833569 | 0.78 | LMNA (0.49) | KMT2AMAPTSMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741758-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |