Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 13/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24631128 | 0.86 | SOS1 (0.50) | LMNAHTTSMN1; SMN2EPAS1SLC6A4 | |
| SCHEMBL24631132 | 0.86 | CA12 (0.54) | LMNAHTTSMN1; SMN2EPAS1SLC6A4 | |
| SCHEMBL24631317 | 0.85 | LMNA (0.49) | LMNAHTTSMN1; SMN2EPAS1BRD4 | |
| SCHEMBL24631133 | 0.85 | EPAS1 (0.50) | LMNAHTTSMN1; SMN2EPAS1SLC6A4 | |
| SCHEMBL24631315 | 0.84 | LMNA (0.50) | LMNAHTTSMN1; SMN2EPAS1BRD4 | |
| SCHEMBL24631135 | 0.83 | ALDH1A1 (0.50) | LMNAHTTSMN1; SMN2EPAS1SLC6A4 | |
| SCHEMBL28750635 | 0.80 | SMN1; SMN2 (0.81) | LMNAHTTSMN1; SMN2SOS1 | |
| SCHEMBL1471508 | 0.80 | FFAR4 (0.60) | LMNA | |
| SCHEMBL4926851 | 0.77 | POLB (0.62) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL22718133 | 0.77 | EPAS1 (0.50) | EPAS1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022177869-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2022-08-25 | — | — | WO | disclosed |
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |