SCHEMBL21192501

SCHEMBL21192501

N#CCCCc1ccc(N)cc1N

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.39
SLC6A4 P31645 1/20 0.39
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
CASP1 P29466 1/20 0.33
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
TKT P29401 1/20 0.30
KDM4E B2RXH2 1/20 0.30
USP2 O75604 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MDM4 O15151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21192492 0.89 MEN1 (0.41) SLC6A4ATMMEN1KMT2ACASP1
SCHEMBL3656732 0.82 MPO (0.43) MPOSLC6A4ATML3MBTL1MEN1
SCHEMBL126188 0.82 CASP1 (0.42) ATML3MBTL1MEN1KMT2ACASP1
SCHEMBL29377795 0.82 CASP1 (0.42) ATML3MBTL1MEN1KMT2ACASP1
SCHEMBL10894932 0.82 CASP1 (0.42) ATML3MBTL1MEN1KMT2ACASP1
Hydrochloric Acid SCHEMBL5240582 0.80 CASP1 (0.41) ATMMEN1KMT2ACASP1GAA
Hydrochloric Acid SCHEMBL10893099 0.80 CASP1 (0.41) ATML3MBTL1MEN1KMT2ACASP1
SCHEMBL28022671 0.79 RAD52 (0.35) CASP1GAAMAPTTSHRMAPK1
SCHEMBL10890416 0.77 CASP1 (0.46) ATMMEN1KMT2ACASP1GAA
SCHEMBL6751703 0.77 ATM (0.41) MPOSLC6A4ATML3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3515898-A1 METHOD FOR THE PREPARATION OF POLYAMINES FROM DINITRILES AND/OR AMINO NITRILES BASF SE (DE) 2019-07-31 EP disclosed