Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 16/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201152 | 0.90 | CBLB (0.55) | CBLBAKR1C3POLBMAPT | |
| SCHEMBL22944961 | 0.87 | CBLB (0.62) | CBLBAKR1C3 | |
| SCHEMBL29640139 | 0.87 | CBLB (0.62) | CBLBAKR1C3 | |
| SCHEMBL21212207 | 0.81 | CBLB (1.00) | CBLB | |
| SCHEMBL29866823 | 0.81 | CBLB (1.00) | CBLB | |
| SCHEMBL21201358 | 0.79 | CBLB (1.00) | CBLBAKR1C3 | |
| SCHEMBL21201359 | 0.79 | CBLB (1.00) | CBLBAKR1C3 | |
| SCHEMBL22944950 | 0.78 | CBLB (0.52) | CBLBAKR1C3 | |
| SCHEMBL29640156 | 0.78 | CBLB (0.52) | CBLBAKR1C3 | |
| SCHEMBL21200402 | 0.77 | CBLB (0.54) | CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |