Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 11/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21200198 | 0.90 | CBLB (0.66) | CBLBAKR1C3MAPTPOLB | |
| SCHEMBL22944950 | 0.87 | CBLB (0.52) | CBLBAKR1C3CYP3A4CYP2C19ACSS2 | |
| SCHEMBL29640156 | 0.87 | CBLB (0.52) | CBLBAKR1C3CYP3A4CYP2C19ACSS2 | |
| SCHEMBL21200369 | 0.81 | AKR1C3 (0.40) | CBLBAKR1C3MAPTALDH1A1CYP3A4 | |
| SCHEMBL29640139 | 0.78 | CBLB (0.62) | CBLBAKR1C3ACSS2 | |
| SCHEMBL22944961 | 0.78 | CBLB (0.62) | CBLBAKR1C3ACSS2 | |
| SCHEMBL28741753 | 0.77 | CBLB (0.50) | CBLBMAPTMEN1KMT2ALMNA | |
| SCHEMBL21201116 | 0.75 | CBLB (0.44) | CBLBMAPTPOLBLMNAGAA | |
| SCHEMBL17925886 | 0.72 | MEN1 (0.57) | MAPTPOLBALDH1A1CYP3A4CYP2C9 | |
| Ammonia Solution, Strong SCHEMBL28873301 | 0.71 | MAPT (0.55) | MAPTALDH1A1MEN1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |