Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 2/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19597220 | 0.90 | KDM4C (0.47) | KMOKDM4CPOLBKMT2AGRM2 | |
| SCHEMBL18731894 | 0.85 | MAPT (0.43) | KMOKDM4CPOLBKMT2AGRM2 | |
| SCHEMBL17678224 | 0.82 | GRM2 (0.47) | KMOKMT2AGRM2SLC22A12ADORA2A | |
| SCHEMBL17610157 | 0.82 | KDM4C (0.46) | KMOKDM4CPOLBKMT2AGRM2 | |
| SCHEMBL14752235 | 0.80 | ADORA2A (0.62) | KMOKDM4CSLC22A12ADORA2AADORA2B | |
| SCHEMBL19335054 | 0.77 | KDM4C (0.47) | KDM4CPOLBKMT2AGRM2HTR2A | |
| SCHEMBL19597250 | 0.76 | KDM4C (0.50) | KDM4CPOLBKMT2AGRM2HTR2C | |
| SCHEMBL21204911 | 0.75 | KMO (0.57) | KMOKDM4CSLC22A12ADORA2AADORA2B | |
| SCHEMBL15802435 | 0.75 | KDM4C (0.47) | KDM4CPOLBKMT2AGRM2HTR2A | |
| SCHEMBL18982536 | 0.74 | CTSK (0.41) | KDM4CGRM2HTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194387-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2019-07-31 | — | — | EP | disclosed |