Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 7/20 | 0.43 |
| ▸ | JAK1 | P23458 | 6/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319816 | 0.82 | AXL (0.43) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL1082037 | 0.81 | AXL (0.47) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL24495812 | 0.80 | JAK2 (0.53) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL2632955 | 0.79 | NUDT1 (0.50) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL31403755 | 0.79 | NUDT1 (0.50) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL18416820 | 0.74 | PRKCI (0.50) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL6128699 | 0.73 | PRKCI (0.45) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL27105519 | 0.72 | JAK3 (0.47) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL20597839 | 0.71 | AXL (0.43) | NUDT1JAK3JAK1AXLPRKCI | |
| SCHEMBL20990227 | 0.70 | NUDT1 (0.65) | NUDT1JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019090158-A9 | SUBSTITUTED PYRROLOPYRIMIDINE JAK INHIBITORS AND METHODS OF MAKING AND USING THE SAME | ACLARIS THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |