Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 13/20 | 0.38 |
| ▸ | JAK3 | P52333 | 11/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.35 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21207663 | 0.82 | NUDT1 (0.48) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL6128699 | 0.79 | PRKCI (0.45) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL21207531 | 0.76 | JAK1 (0.55) | JAK1JAK3JAK2 | |
| SCHEMBL1082037 | 0.75 | AXL (0.47) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL21207566 | 0.75 | JAK1 (0.54) | JAK1JAK3JAK2 | |
| SCHEMBL21207563 | 0.74 | JAK3 (0.53) | JAK1JAK3JAK2 | |
| SCHEMBL24495812 | 0.74 | JAK2 (0.53) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL2632955 | 0.73 | NUDT1 (0.50) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL31403755 | 0.73 | NUDT1 (0.50) | AXLPRKCINUDT1JAK1JAK3 | |
| SCHEMBL21207599 | 0.72 | JAK2 (0.33) | AXLPRKCINUDT1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022067106-A1 | CRYSTALLINE POLYMORPH FORM A OF A JAK INHIBITOR AND METHODS FOR ITS PREPARATION | ACLARIS THERAPEUTICS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |