Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592983 | 0.94 | SMN1; SMN2 (0.49) | ADRB2ADRB1ADRB3SMN1; SMN2HTT | |
| SCHEMBL1343622 | 0.87 | NPC1 (0.57) | ADRB2ADRB1ADRB3SMN1; SMN2HTT | |
| SCHEMBL12147816 | 0.87 | NPC1 (0.50) | ADRB2ADRB1ADRB3SMN1; SMN2HTT | |
| SCHEMBL17162099 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3SMN1; SMN2LMNA | |
| SCHEMBL21405274 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3HTTMEN1 | |
| SCHEMBL23720535 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3HTTMEN1 | |
| SCHEMBL16346320 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3SMN1; SMN2LMNA | |
| SCHEMBL17162054 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3HTTMEN1 | |
| SCHEMBL30380314 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3SMN1; SMN2LMNA | |
| SCHEMBL30380648 | 0.85 | TSHR (0.52) | ADRB2ADRB1ADRB3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148055-A9 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019148055-A1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-08-01 | — | — | WO | disclosed |