Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796241 | 0.81 | FLT3 (0.57) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL21208173 | 0.81 | DYRK1A (0.55) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL376358 | 0.81 | KIT (0.53) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL29868755 | 0.81 | PKM (0.54) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL1995553 | 0.81 | KIT (0.53) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL2650330 | 0.79 | FLT3 (0.74) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL1997512 | 0.78 | DYRK1A (0.52) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL21208267 | 0.78 | DYRK1A (0.52) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL25789349 | 0.77 | FLT3 (0.67) | KITDYRK1AFLT3IRAK4PKM | |
| SCHEMBL21217156 | 0.76 | IRAK4 (0.56) | KITDYRK1AFLT3IRAK4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148136-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |