Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MTR | Q99707 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10074206 | 0.79 | CRBN (0.45) | CRBNCSNK1A1DDB1IKZF3BRD4 | |
| SCHEMBL7856696 | 0.79 | CRBN (0.45) | CRBNCSNK1A1DDB1IKZF3BRD4 | |
| SCHEMBL7850526 | 0.79 | CRBN (0.62) | CRBNCSNK1A1DDB1IKZF3BRD4 | |
| SCHEMBL20075961 | 0.78 | GAA (0.46) | CRBNKMT2ARAB9ADDB1IKZF3 | |
| SCHEMBL442296 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL7284377 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL410243 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL410700 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL10074217 | 0.76 | CRBN (0.43) | CRBNCSNK1A1DDB1IKZF3BRD4 | |
| SCHEMBL23919161 | 0.75 | CRBN (0.60) | CRBNKMT2AMTRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220515-B2 | Imide-based modulators of proteolysis and associated methods of use | YALE UNIVERSITY (US) | 2022-01-11 | — | — | US | disclosed |
| US-20190233433-A1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | YALE UNIVERSITY | 2019-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220515-B2 | Imide-based modulators of proteolysis and associated methods of use | CRBN, MDM2, UBE2N | CRBN 1/4885KMT2A 1660/4885MTR 2298/4885 |
| US-20190233433-A1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | CRBN, MDM2, UBE2N | CRBN 1/4885KMT2A 1660/4885MTR 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.