Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24180094 | 0.94 | RIPK1 (0.55) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL561124 | 0.81 | RIPK1 (0.63) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL284472 | 0.81 | ALDH1A1 (0.61) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24309358 | 0.80 | RIPK1 (0.51) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22957616 | 0.80 | RIPK1 (0.57) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL560790 | 0.77 | RIPK1 (0.63) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8549973 | 0.77 | RIPK1 (0.63) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8252603 | 0.77 | RIPK1 (0.63) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22095406 | 0.77 | RIPK1 (0.51) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22095407 | 0.77 | RIPK1 (0.51) | RIPK1KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019147782-A1 | AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-01 | — | — | WO | disclosed |