Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610385 | 0.98 | ROCK2 (0.49) | ROCK2ROCK1POLBCDC7SMYD3 | |
| SCHEMBL24610411 | 0.97 | ROCK2 (0.49) | ROCK2ROCK1POLBSMYD3SYK | |
| SCHEMBL21217790 | 0.91 | ROCK2 (0.53) | ROCK2ROCK1POLBSMYD3SYK | |
| SCHEMBL24094396 | 0.91 | ROCK2 (0.53) | ROCK2ROCK1POLBSMYD3SYK | |
| SCHEMBL21217793 | 0.90 | ROCK2 (0.43) | ROCK2ROCK1SYK | |
| SCHEMBL24610384 | 0.88 | ROCK2 (0.47) | ROCK2ROCK1POLB | |
| SCHEMBL24610388 | 0.87 | ROCK1 (0.50) | ROCK2ROCK1 | |
| SCHEMBL24094285 | 0.86 | NPC1 (0.40) | ROCK2ROCK1 | |
| SCHEMBL21217816 | 0.85 | MEN1 (0.40) | ROCK2ROCK1POLB | |
| SCHEMBL22966755 | 0.84 | ROCK2 (0.59) | ROCK2ROCK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |