Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 16/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | STK3 | Q13188 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217534 | 0.93 | ROCK1 (0.45) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24094285 | 0.89 | NPC1 (0.40) | ROCK1ROCK2CLK4MEN1KMT2A | |
| SCHEMBL24610384 | 0.89 | ROCK2 (0.47) | ROCK1ROCK2MEN1KMT2ANPC1 | |
| SCHEMBL21217863 | 0.88 | ROCK1 (0.40) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL21217816 | 0.88 | MEN1 (0.40) | ROCK1ROCK2MEN1KMT2ANPC1 | |
| SCHEMBL24610385 | 0.87 | ROCK2 (0.49) | ROCK1ROCK2 | |
| SCHEMBL21217529 | 0.87 | ROCK2 (0.51) | ROCK1ROCK2 | |
| SCHEMBL24610411 | 0.87 | ROCK2 (0.49) | ROCK1ROCK2MEN1KMT2ANPC1 | |
| SCHEMBL21217791 | 0.87 | ROCK2 (0.41) | ROCK1ROCK2 | |
| SCHEMBL24094323 | 0.86 | ROCK2 (0.48) | ROCK1ROCK2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |