Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094355 | 0.82 | ROCK1 (0.48) | MEN1KMT2ANPC1ROCK2ROCK1 | |
| SCHEMBL24094395 | 0.81 | ROCK2 (0.48) | MEN1KMT2AROCK2ROCK1 | |
| SCHEMBL21217914 | 0.81 | ROCK2 (0.48) | ROCK2ROCK1 | |
| SCHEMBL24610390 | 0.79 | ROCK1 (0.46) | ROCK2ROCK1 | |
| SCHEMBL24094088 | 0.79 | ROCK1 (0.47) | MEN1KMT2ANPC1EGFRROCK2 | |
| SCHEMBL22966949 | 0.76 | MAOB (0.46) | MEN1KMT2ANPC1EGFRROCK2 | |
| SCHEMBL24094285 | 0.76 | NPC1 (0.40) | MEN1KMT2ANPC1EGFRROCK2 | |
| SCHEMBL21217819 | 0.76 | ROCK2 (0.43) | ROCK2ROCK1 | |
| SCHEMBL24610411 | 0.74 | ROCK2 (0.49) | MEN1KMT2ANPC1ROCK2ROCK1 | |
| SCHEMBL24610388 | 0.74 | ROCK1 (0.50) | MEN1KMT2ANPC1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |