Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 10/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 16/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094338 | 0.92 | ROCK1 (0.41) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610420 | 0.83 | ROCK1 (0.45) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610388 | 0.80 | ROCK1 (0.50) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610234 | 0.80 | ROCK1 (0.43) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610393 | 0.79 | ROCK2 (0.43) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL22966832 | 0.79 | ROCK1 (0.47) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL22966739 | 0.79 | ROCK1 (0.47) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL21217534 | 0.78 | ROCK1 (0.45) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL21217627 | 0.76 | ROCK1 (0.41) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610308 | 0.75 | ROCK1 (0.43) | ROCK1ROCK2CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |