Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21450553 | 0.91 | HDAC1 (0.43) | HDAC1HDAC6ALDH1A1KDM4EALOX15 | |
| SCHEMBL18593252 | 0.81 | KDM4E (0.64) | HDAC1HDAC6ALDH1A1KDM4EALOX15 | |
| SCHEMBL25292482 | 0.78 | MAPT (0.48) | HDAC1HDAC6ALDH1A1MAPTPOLB | |
| SCHEMBL21226551 | 0.77 | HDAC1 (0.42) | HDAC1HDAC6ALDH1A1GFERMAPT | |
| SCHEMBL22397595 | 0.76 | MPO (0.55) | HDAC1HDAC6ALDH1A1KDM4EALOX15 | |
| SCHEMBL18593249 | 0.76 | NOTUM (0.64) | HDAC1HDAC6KDM4EMAPTPOLB | |
| SCHEMBL29913803 | 0.75 | NOTUM (0.39) | ALDH1A1KDM4EALOX15CASP1CASP7 | |
| SCHEMBL21450554 | 0.75 | HDAC1 (0.42) | HDAC1HDAC6ALDH1A1GFERMAPT | |
| SCHEMBL31607953 | 0.70 | SMN1; SMN2 (0.50) | ALDH1A1MAPTRAB9A | |
| SCHEMBL31341976 | 0.70 | L3MBTL1 (0.48) | ALDH1A1ALOX15HSD17B10MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139439-A1 | [6,6] FUSED BICYCLIC HDAC8 INHIBITORS | VALO HEALTH, INC. | 2021-05-13 | — | — | US | disclosed |
| US-10370343-B2 | [6,6] Fused bicyclic HDAC8 inhibitors | FORMA THERAPEUTICS, INC. (US) | 2019-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139439-A1 | [6,6] FUSED BICYCLIC HDAC8 INHIBITORS | HDAC8, HDAC3, HDAC2 | HDAC1 4/4885HDAC6 10/4885ALDH1A1 1338/4885 |
| US-10370343-B2 | [6,6] Fused bicyclic HDAC8 inhibitors | HDAC8, HDAC3, HDAC2 | HDAC1 4/4885HDAC6 10/4885ALDH1A1 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.