Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.55 |
| ▸ | CA9 | Q16790 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28456685 | 0.90 | KDR (0.65) | KDRPDGFRBTRPV1CA9CA1 | |
| SCHEMBL58722 | 0.85 | KDR (0.58) | KDRPDGFRBTRPV1CA9CA1 | |
| SCHEMBL12491436 | 0.84 | MTOR (0.57) | KDRPDGFRBCA9CA1CA2 | |
| SCHEMBL64906 | 0.83 | KDR (0.64) | KDRPDGFRBTRPV1CA9CA1 | |
| SCHEMBL19677976 | 0.81 | KDR (0.88) | KDRTRPV1CA9CA1CA2 | |
| SCHEMBL5675377 | 0.80 | PDGFRB (0.58) | KDRPDGFRBCA9CA1CA2 | |
| SCHEMBL60880 | 0.79 | KDR (0.56) | KDRPDGFRBTRPV1CA9CA1 | |
| SCHEMBL15932600 | 0.79 | RAB9A (0.55) | KDRPDGFRBCA9CA1CA2 | |
| SCHEMBL3197169 | 0.79 | MAPT (0.56) | KDRPDGFRBTRPV1CA9CA1 | |
| SCHEMBL17669988 | 0.79 | KDR (0.66) | KDRPDGFRBTRPV1CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3045457-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2016-07-20 | — | — | EP | disclosed |
| US-8969366-B2 | Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-03 | — | — | US | disclosed |
| US-20130345245-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-12-26 | — | — | US | disclosed |
| US-8546413-B2 | Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-10-01 | — | — | US | disclosed |
| US-20120178770-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-07-12 | — | — | US | disclosed |
| EP-2443117-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145998-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345245-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | MAP3K5, MAP3K9, MAP3K1 | KDR 886/4885PDGFRB 270/4885TRPV1 4154/4885 |
| US-20120178770-A1 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | MAP3K5, MAP3K9, MAP3K1 | KDR 886/4885PDGFRB 270/4885TRPV1 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.