Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59604 | 0.88 | KMT2A (0.61) | MTORBAZ1AKDRPDGFRBMEN1 | |
| SCHEMBL14033133 | 0.87 | KDR (0.57) | MTORKDRPDGFRBMEN1MAPT | |
| SCHEMBL5675377 | 0.86 | PDGFRB (0.58) | EPHX2KDRPDGFRBMEN1MAPT | |
| SCHEMBL15932600 | 0.85 | RAB9A (0.55) | KDRPDGFRBMEN1MAPTHTT | |
| SCHEMBL2122840 | 0.84 | KDR (0.61) | KDRPDGFRBCA1CA2CA9 | |
| SCHEMBL15932598 | 0.82 | RAB9A (0.55) | KDRPDGFRBMEN1MAPTHTT | |
| SCHEMBL3308119 | 0.81 | MEN1 (0.61) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL423849 | 0.81 | PDGFRB (0.54) | EPHX2KDRPDGFRBMEN1MAPT | |
| SCHEMBL15917735 | 0.81 | CA2 (0.54) | KDRPDGFRBMEN1RAB9AKMT2A | |
| SCHEMBL73204 | 0.81 | L3MBTL1 (0.50) | MTORKDRPDGFRBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150232452-A1 | NOVEL RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2015-08-20 | — | — | US | disclosed |
| US-20150232452-A1 | NOVEL RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2015-08-20 | — | — | US | disclosed |
| US-20150232452-A1 | NOVEL RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2015-08-20 | — | — | US | disclosed |
| US-20140221374-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221374-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221374-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION (US) | 2014-08-07 | — | — | US | disclosed |
| EP-2686317-A2 | RAF KINASE INHIBITORS | Selexagen Therapeutics, Inc. (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012125981-A2 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2012-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221374-A1 | RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | MTOR 179/4885BAZ1A 655/4885EPHX2 1692/4885 |
| US-20150232452-A1 | NOVEL RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | MTOR 204/4885BAZ1A 638/4885EPHX2 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.