Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054616 | 0.87 | TDP1 (0.48) | TDP1SNCAHDAC2HDAC3HDAC4 | |
| SCHEMBL21229101 | 0.85 | GAA (0.51) | TDP1MAPK8 | |
| SCHEMBL21229095 | 0.84 | GAA (0.36) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18667020 | 0.83 | TDP1 (0.44) | TDP1SNCA | |
| SCHEMBL26140316 | 0.78 | TDP1 (0.55) | TDP1 | |
| SCHEMBL10233477 | 0.76 | TDP1 (0.57) | TDP1 | |
| SCHEMBL3071381 | 0.76 | LMNA (0.43) | TDP1HDAC2HDAC3HDAC4HDAC1 | |
| SCHEMBL18641473 | 0.75 | TDP1 (0.55) | TDP1 | |
| SCHEMBL18641366 | 0.75 | TDP1 (0.49) | TDP1SNCAHDAC2 | |
| SCHEMBL3168739 | 0.74 | TDP1 (0.58) | TDP1SNCAHDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377748-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2019-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377748-B2 | Hepatitis B core protein modulators | HAVCR2, FABP1, MAVS | TDP1 4337/4885SNCA 3703/4885HDAC2 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.