Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29374581 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL8066143 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL447074 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2787196 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL21626215 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL29051415 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL5328814 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL4818290 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL3657 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2235356 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 610 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324908-A | Preservation solution of anti-HCG antibody and application thereof | 厦门康基生物科技有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-113425835-B | Growth hormone crude drug solution, water injection and preparation method thereof | 常州健益生物制药有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-116410294-A | Preparation and purification method of monopolyethylene glycol recombinant human erythropoietin | 华润昂德生物药业有限公司 | 2023-07-11 | — | — | CN | claimed |
| CN-116271340-A | Prefilled nanometer carbon suspension injection and preparation method thereof | 重庆莱美药业股份有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-115656292-A | Method for measuring fluorine content in adhesive | 包头钢铁（集团）有限责任公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115144345-A | Method for measuring titer of trace thrombin in human activated coagulation factor VII concentrated preparation | 上海莱士血液制品股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-114698684-A | Plum freeze-drying process | 四川轻化工大学 | 2022-07-05 | — | — | CN | claimed |
| CN-114674876-A | Method for improving accuracy and sensitivity of detecting fluorine content in iron phosphate | 河南佰利新能源材料有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-112481343-B | Method for producing collagen peptide by using cod skin raw material | 山东恒鑫生物科技有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-113425835-A | Growth hormone raw material medicine solution, water injection and preparation method thereof | 常州健益生物制药有限公司 | 2021-09-24 | — | — | CN | claimed |
| WO-2016161421-A1 | A METHOD OF MANUFACTURING INTRAVENOUS IMMUNOGLOBULIN FROM FRACTION III | HOANG KIEU (US) | 2016-10-06 | — | — | WO | claimed |
| CN-104387466-A | Method for separating fibrinogen from Cohn component I sediment | GUIZHOU ZHONGTAI BIOTECHNOLOGY CO LTD | 2015-03-04 | — | — | CN | claimed |
| CN-101919811-A | Levetiracetam injection and preparation method thereof | BEIJING BOSHI ANTAI LIQUID PREPARATION TECHNOLOGY CO LTD | 2010-12-22 | — | — | CN | claimed |
| CN-101122562-A | Oligonucleotide chip for detecting transplanted kidney function and its uses | UNIV ZHEJIANG (CN) | 2008-02-13 | — | — | CN | claimed |
| EP-0910387-B1 | APOPTOSIS ASSOCIATED PROTEIN BBK | IMMUNOGEN INC (US) | 2007-11-28 | — | — | EP | claimed |
| US-6057132-A | NUCLEOTIDE SEQUENCE CODING FOR A PROTEIN ASSOCIATED WITH DEFECTIVE CELL PROPAGATIVE STATES; FOR THE TREATMENT OF CELL DEGRADATIVE DEFECTS, CANCER, AUTOIMMUNE DISEASES AND NERVOUS SYSTEM DISORDERS | IMMUNOGEN, INC. (US) | 2000-05-02 | — | — | US | claimed |
| US-5998141-A | METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF DEVELOPING A DISEASE WHICH IS ASSOCIATED WITH A SPECIFIC ALLELE OF A POLYMORPHIC REGION OF AN SR-BI GENE, AND KITS FOR PERFORMING SUCH METHODS. | MILLENNIUM PHARMACEUTICALS, INC. (US) | 1999-12-07 | — | — | US | claimed |
| US-5466781-A | Isolation of bodies, suspension, agitation and centrifuging | CHIRON THERAPEUTICS (US) | 1995-11-14 | — | — | US | claimed |
| EP-0031826-B1 | PROCESS FOR MONITORING THE HISTORY OF TEMPERATURE VERSUS TIME OF DEEP-FROZEN PRODUCT, INDICATOR FOR APPLYING SAID PROCESS AND UTILIZATION OF SAID PROCESS | ALLMENDINGER, Thomas (CH) | 1984-05-30 | — | — | EP | claimed |
| US-4404132-A | FREE OF THROMBIN, HEPARIN, THROMBOPLASTIN ACTIVITY | CUTTER LABORATORIES, INC. (US) | 1983-09-13 | — | — | US | claimed |