Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.90 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29374581 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL212319 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL9299265 | 0.97 | CA4 (0.84) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL1065771 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL8066143 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL15173183 | 0.97 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL4818290 | 0.95 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL21626215 | 0.95 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL29051415 | 0.95 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2787196 | 0.95 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105640925-B | Dried powder formula and method for treating pulmonary disease | 普马特里克斯营业公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-108434126-A | Treat the dry powder formulation and method of tuberculosis | 普马特里克斯营业公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-103200938-B | Dry powder formulations and methods for treating pulmonary diseases | 普马特里克斯营业公司 | 2018-07-31 | — | — | CN | disclosed |
| US-20180153996-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING CO INC (US) | 2018-06-07 | — | — | US | disclosed |
| CN-102497853-B | Dry powder formulations and methods for treating pulmonary diseases | 普马特里克斯营业公司 | 2018-03-23 | — | — | CN | disclosed |
| US-9238005-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-9233158-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20150335573-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-11-26 | — | — | US | disclosed |
| US-20150250875-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. | 2015-09-10 | — | — | US | disclosed |
| US-9119778-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX OPERATING COMPANY, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20150196486-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2015-07-16 | — | — | US | disclosed |
| US-9061352-B2 | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20130213398-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX OPERATING COMPANY, INC. | 2013-08-22 | — | — | US | disclosed |
| CN-103200938-A | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX INC | 2013-07-10 | — | — | CN | disclosed |
| CN-102497853-A | Dry powder formulations and methods for treating pulmonary diseases | PULMATRIX INC | 2012-06-13 | — | — | CN | disclosed |
| US-20120064126-A1 | DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES | PULMATRIX, INC. (US) | 2012-03-15 | — | — | US | disclosed |