Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 4/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | Q9HBH1 | 1/20 | 0.39 | |
| ▸ | CALCRL | Q16602 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946450 | 0.91 | FURIN (0.42) | FURINKLKB1HTTPDFCALCRL | |
| SCHEMBL24297300 | 0.86 | FURIN (0.46) | FURINHTTCHRNA1CHRNGCHRNB1 | |
| SCHEMBL24297312 | 0.86 | FURIN (0.46) | FURINHTTCHRNA1CHRNGCHRNB1 | |
| SCHEMBL27447192 | 0.85 | FURIN (0.39) | FURINKLKB1HTTCHRNA1CHRNG | |
| SCHEMBL24916488 | 0.85 | FURIN (0.48) | FURINHTTCHRNA1CHRNGCHRNB1 | |
| SCHEMBL22138596 | 0.85 | FURIN (0.39) | FURINKLKB1HTTCHRNA1CHRNG | |
| SCHEMBL22138594 | 0.85 | FURIN (0.39) | FURINKLKB1HTTCHRNA1CHRNG | |
| SCHEMBL20705515 | 0.85 | FURIN (0.39) | FURINKLKB1HTTCHRNA1CHRNG | |
| SCHEMBL24296990 | 0.85 | FURIN (0.40) | FURINKLKB1HTTCHRNA1CHRNG | |
| SCHEMBL22138373 | 0.84 | FURIN (0.45) | FURINHTTCHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521292-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | Pfizer Inc (US) | 2019-08-07 | — | — | EP | disclosed |