Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 7/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | Q9HBH1 | 1/20 | 0.36 | |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21234897 | 0.91 | FURIN (0.48) | FURINKLKB1CALCRLCHRNA1CHRNG | |
| SCHEMBL16645118 | 0.91 | FURIN (0.47) | FURINKLKB1CALCRLSSTR3PDF | |
| SCHEMBL16949521 | 0.86 | FURIN (0.36) | FURINKLKB1CALCRLCHRNA1CHRNG | |
| SCHEMBL24774284 | 0.85 | FURIN (0.40) | FURINCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL15699830 | 0.85 | SIRT5 (0.39) | FURINCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL25680283 | 0.85 | FURIN (0.40) | FURINCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL23051312 | 0.84 | MAP1LC3B (0.38) | FURINCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL22138594 | 0.84 | FURIN (0.39) | FURINKLKB1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL20705515 | 0.84 | FURIN (0.39) | FURINKLKB1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL22138596 | 0.84 | FURIN (0.39) | FURINKLKB1CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150209445-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | PFIZER INC. | 2015-07-30 | — | — | US | disclosed |
| WO-2015110935-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | PFIZER INC. (US) | 2015-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150209445-A1 | BIFUNCTIONAL CYTOTOXIC AGENTS | PAICS, CYTH3, CYTH2 | FURIN 3455/4885KLKB1 1725/4885CALCRL 4148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.