Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.61 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970557 | 0.82 | KCNK3 (0.70) | BRAFMAPTRAB9AHTTSMN1; SMN2 | |
| SCHEMBL19662798 | 0.81 | NT5E (0.70) | BRAFBCAT2CSF1RGRM5RAB9A | |
| SCHEMBL20435085 | 0.79 | KCNK3 (0.76) | BRAFMAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3707848 | 0.78 | MAPT (0.58) | BRAFCSF1RMAPTRAB9AHTT | |
| SCHEMBL6816845 | 0.78 | MAPT (0.62) | BRAFCSF1RMAPTRAB9AHTT | |
| SCHEMBL12763862 | 0.78 | KCNK3 (0.75) | BRAFMAPTRAB9AHTTKDM4E | |
| SCHEMBL27749505 | 0.78 | MAPT (0.62) | BRAFCSF1RMAPTRAB9AHTT | |
| SCHEMBL10428582 | 0.78 | MAPT (0.62) | BRAFCSF1RMAPTRAB9AHTT | |
| SCHEMBL3639173 | 0.78 | KCNK3 (0.68) | BRAFCSF1RMAPTRAB9AHTT | |
| SCHEMBL19662757 | 0.78 | BCAT2 (0.66) | BRAFBCAT2GRM5MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | BRAF 988/4885BCAT2 3212/4885CSF1R 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.