⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12563132 | 0.72 | MEN1 (0.35) | — | |
| SCHEMBL20844223 | 0.70 | — | — | |
| SCHEMBL20844226 | 0.69 | NOTUM (0.30) | — | |
| SCHEMBL16812507 | 0.68 | GAA (0.34) | — | |
| SCHEMBL20844225 | 0.67 | — | — | |
| SCHEMBL21718639 | 0.67 | — | — | |
| SCHEMBL10201028 | 0.66 | EGFR (0.32) | — | |
| SCHEMBL16166889 | 0.65 | BRPF1 (0.37) | — | |
| SCHEMBL19068273 | 0.64 | L3MBTL1 (0.34) | — | |
| SCHEMBL21719748 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570145-B2 | TYK2 inhibitors and uses thereof | Nimbus Lakshimi, Inc. (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190241577-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-08-08 | — | — | US | disclosed |