Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.57 |
| ▸ | DRD2 | P14416 | 13/20 | 0.57 |
| ▸ | HTR2A | P28223 | 13/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21239146 | 0.90 | HTR1A (0.57) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL21238959 | 0.85 | DRD2 (0.57) | HTR1ADRD2HTR2ASLC6A4DRD3 | |
| SCHEMBL5364977 | 0.84 | HTR1A (0.58) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL5375318 | 0.81 | HTR1A (0.55) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL15534212 | 0.77 | HTR1A (0.59) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL15601661 | 0.77 | DRD2 (0.62) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL17471492 | 0.77 | DRD2 (0.59) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL5363663 | 0.76 | HTR1A (0.61) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL16559710 | 0.76 | HTR1A (0.61) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL5827507 | 0.75 | DRD2 (0.51) | HTR1ADRD2HTR2AKCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847193-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2019-08-07 | — | — | EP | disclosed |