Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342155 | 0.79 | GAA (0.37) | CYP3A4ADRA2AKDM4EMAPTLMNA | |
| SCHEMBL21131297 | 0.77 | CYP3A4 (0.62) | CYP3A4ADRA2AKDM4EMAPTLMNA | |
| SCHEMBL8292092 | 0.77 | CYP3A4 (0.62) | CYP3A4ADRA2AKDM4EMAPTLMNA | |
| SCHEMBL15981344 | 0.75 | KDM4E (0.40) | KDM4EMAPTALDH1A1HPGDPOLB | |
| SCHEMBL10284425 | 0.75 | GAA (0.41) | CYP3A4ADRA2ALMNAHTTGAA | |
| SCHEMBL22080559 | 0.75 | KDM4E (0.40) | KDM4EMAPTALDH1A1HPGDPOLB | |
| SCHEMBL22791425 | 0.75 | GAA (0.37) | CYP3A4ADRA2AKDM4EMAPTHTT | |
| SCHEMBL12305572 | 0.73 | NPC1 (0.47) | CYP3A4ADRA2AKDM4EMAPTLMNA | |
| SCHEMBL16130442 | 0.73 | CYP3A4 (0.40) | CYP3A4ADRA2AKDM4EMAPTLMNA | |
| SCHEMBL12830975 | 0.73 | CYP3A4 (0.40) | CYP3A4ADRA2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521286-B1 | FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 | CANCER RESEARCH TECH LTD (GB) | 2021-09-29 | — | — | EP | disclosed |
| EP-3521286-A1 | FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 | Cancer Research Technology Ltd. (GB) | 2019-08-07 | — | — | EP | disclosed |