Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21239486 | 1.00 | POLB (0.64) | POLBEPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL29874164 | 1.00 | POLB (0.64) | POLBEPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL21239463 | 0.84 | FPR2 (0.57) | HTTMEN1KMT2ANPC1FPR2 | |
| SCHEMBL21239464 | 0.84 | FPR2 (0.57) | HTTMEN1KMT2ANPC1FPR2 | |
| SCHEMBL21239484 | 0.84 | FPR2 (0.57) | HTTMEN1KMT2ANPC1FPR2 | |
| SCHEMBL21239562 | 0.83 | MAPT (0.55) | POLBHTTMEN1LMNAKMT2A | |
| SCHEMBL21239563 | 0.83 | MAPT (0.55) | POLBHTTMEN1LMNAKMT2A | |
| SCHEMBL29873879 | 0.83 | MAPT (0.55) | POLBHTTMEN1LMNAKMT2A | |
| SCHEMBL4622507 | 0.82 | CYP3A4 (0.51) | POLBEPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL21239591 | 0.82 | MEN1 (0.58) | EPHX1HTTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843283-B | Urea derivatives | 第一三共株式会社 | 2022-08-30 | — | — | CN | disclosed |
| US-20220144765-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-05-12 | — | — | US | disclosed |
| US-20220144765-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-05-12 | — | — | US | disclosed |
| US-20210206716-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-07-08 | — | — | US | disclosed |
| US-20210206716-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-07-08 | — | — | US | disclosed |
| US-10968169-B2 | Urea derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-04-06 | — | — | US | disclosed |
| US-10968169-B2 | Urea derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-04-06 | — | — | US | disclosed |
| EP-3524240-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-08-14 | — | — | EP | disclosed |
| CN-109843283-A | Urea derivative | 第一三共株式会社 | 2019-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210206716-A1 | UREA DERIVATIVE | IDO1, IDO2, TPH1 | POLB 4287/4885EPHX1 2395/4885EPHX2 2834/4885 |
| US-10968169-B2 | Urea derivative | IDO1, IDO2, UTS2R | POLB 4183/4885EPHX1 2644/4885EPHX2 3183/4885 |
| US-20220144765-A1 | UREA DERIVATIVE | IDO1, IDO2, TPH1 | POLB 4287/4885EPHX1 2395/4885EPHX2 2834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.