Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 6/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 7/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.42 |
| ▸ | CDK4 | P11802 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 4/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357914 | 0.97 | AHR (0.46) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL2318356 | 0.89 | AHR (0.51) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL15684650 | 0.86 | CCNK (0.47) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL21016907 | 0.85 | AHR (0.44) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL2317564 | 0.82 | AHR (0.62) | AHRCDK2CDK9CCNE1CCNE2 | |
| SCHEMBL20895840 | 0.82 | AHR (0.49) | AHRCDK2CDK9CCNE1CCNE2 | |
| SCHEMBL15010781 | 0.80 | CCNK (0.38) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL13282111 | 0.80 | AHR (0.46) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL2358541 | 0.80 | CCNK (0.52) | AHRCCNKCDK12CDK2CDK9 | |
| SCHEMBL20895820 | 0.80 | CDK2 (0.51) | AHRCCNKCDK12CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524604-A1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2019-08-14 | — | — | EP | disclosed |