Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 6/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 10/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 9/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.43 |
| ▸ | CDK4 | P11802 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.43 |
| ▸ | CDK7 | P50613 | 6/20 | 0.43 |
| ▸ | CCNH | P51946 | 5/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15684650 | 0.89 | CCNK (0.47) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL2358830 | 0.86 | CCNK (0.48) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL3501809 | 0.85 | AHR (0.51) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL2318356 | 0.84 | AHR (0.51) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL2314268 | 0.84 | CDK2 (0.45) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL2317564 | 0.84 | AHR (0.62) | AHRCDK2CCNE1CCNE2CCNA2 | |
| SCHEMBL25308712 | 0.83 | CCNK (0.66) | CCNKCDK12CDK2CCNE1CCNE2 | |
| SCHEMBL30518542 | 0.83 | CCNK (0.66) | CCNKCDK12CDK2CCNE1CCNE2 | |
| SCHEMBL2317298 | 0.83 | AHR (0.50) | CCNKCDK12AHRCDK2CCNE1 | |
| SCHEMBL2357914 | 0.83 | AHR (0.46) | CCNKCDK12AHRCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524604-B1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | NOVARTIS AG (CH) | 2023-03-29 | — | — | EP | disclosed |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| EP-3524604-A1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2019-08-14 | — | — | EP | disclosed |
| EP-2788476-B1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | HUTCHINSON FRED CANCER RES (US) | 2019-05-22 | — | — | EP | disclosed |
| EP-2350078-B1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2019-04-17 | — | — | EP | disclosed |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2018-05-24 | — | — | US | disclosed |
| US-9834755-B2 | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-9580426-B2 | Compounds that expand hematopoietic stem cells | NOVARTIS AG (CH) | 2017-02-28 | — | — | US | disclosed |
| US-9567569-B2 | Methods of culturing and expanding mesenchymal stem cells | GAMIDA CELL LTD. (IL) | 2017-02-14 | — | — | US | disclosed |
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-12-18 | — | — | US | disclosed |
| EP-2788476-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | Fred Hutchinson Cancer Research Center (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-24 | — | — | US | disclosed |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| WO-2013086436-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2013-06-13 | — | — | WO | disclosed |
| CN-102203096-A | Compounds that expand hematopoietic stem cells | IRM LLC | 2011-09-28 | — | — | CN | disclosed |
| EP-2350078-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2011-08-03 | — | — | EP | disclosed |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
| WO-2010059401-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | CCNK 2763/4885CDK12 3711/4885AHR 1/4885 |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CCNK 2896/4885CDK12 2618/4885AHR 525/4885 |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CCNK 2896/4885CDK12 2618/4885AHR 525/4885 |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CCNK 2896/4885CDK12 2618/4885AHR 525/4885 |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | PBK, IL2, AHR | CCNK 211/4885CDK12 1748/4885AHR 3/4885 |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | CCNK 2896/4885CDK12 2618/4885AHR 525/4885 |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | AHR, HGF, MTNR1A | CCNK 3442/4885CDK12 4424/4885AHR 1/4885 |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | CCNK 2763/4885CDK12 3711/4885AHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.