Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21239907 | 1.00 | ADORA2A (0.46) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL13394505 | 0.81 | ADORA2A (0.55) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL18713682 | 0.80 | ADORA2A (0.50) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL24759258 | 0.78 | ADORA2A (0.52) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL19441842 | 0.78 | ADORA2A (0.52) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL24759259 | 0.78 | ADORA2A (0.52) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL19003532 | 0.78 | ADORA2A (0.41) | ADORA2AADORA2BLSSGRM4MCHR1 | |
| SCHEMBL23135082 | 0.77 | KEAP1 (0.35) | ADORA2AADORA2BGRM4 | |
| SCHEMBL19236877 | 0.75 | KEAP1 (0.49) | — | |
| SCHEMBL26740887 | 0.72 | ADORA2A (0.52) | ADORA2AADORA2BLSSGRM4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |