SCHEMBL21240965

SCHEMBL21240965

Cc1ccc2c(c1)c(Cl)cc1ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.47
MAPT P10636 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
LMNA P02545 3/20 0.46
CYP2A6 P11509 3/20 0.44
TDP1 Q9NUW8 1/20 0.43
HPRT1 P00492 2/20 0.43
MAOA P21397 1/20 0.42
TRPM4 Q8TD43 1/20 0.41
ALDH1A1 P00352 4/20 0.41
CDC25B P30305 1/20 0.41
UBE2I P63279 1/20 0.41
SAE1 Q9UBE0 1/20 0.41
UBA2 Q9UBT2 1/20 0.41
KDM4E B2RXH2 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KIF11 P52732 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
HIF1A Q16665 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1922076 0.81 ALDH1A1 (0.55) CYP1A2MAPTL3MBTL1LMNACYP2A6
SCHEMBL30494614 0.81 ALDH1A1 (0.55) CYP1A2MAPTL3MBTL1LMNACYP2A6
SCHEMBL598782 0.79 HPRT1 (0.64) CYP1A2MAPTLMNACYP2A6TDP1
SCHEMBL28996719 0.79 HPRT1 (0.64) CYP1A2MAPTLMNACYP2A6TDP1
SCHEMBL599225 0.79 HPRT1 (0.64) CYP1A2MAPTL3MBTL1CYP2A6TDP1
SCHEMBL216959 0.77 CYP2A6 (0.65) CYP1A2MAPTL3MBTL1LMNACYP2A6
SCHEMBL30540087 0.77 CYP2A6 (0.65) CYP1A2MAPTL3MBTL1LMNACYP2A6
SCHEMBL18597039 0.77 HPRT1 (0.60) CYP1A2LMNACYP2A6TDP1HPRT1
SCHEMBL17180585 0.76 KIF11 (0.54) CYP1A2MAPTLMNACYP2A6TDP1
SCHEMBL8840916 0.76 KIF11 (0.54) CYP1A2MAPTLMNACYP2A6TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019149260-A1 PYRIDAZINOL COMPOUND, DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2019-08-08 WO disclosed