Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.55 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.52 |
| ▸ | PTPRB | P23467 | 1/20 | 0.49 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522727 | 1.00 | CTSS (0.59) | CTSSCTSKHDAC4HDAC1HDAC2 | |
| SCHEMBL21224490 | 0.90 | HDAC4 (0.57) | CTSSCTSKHDAC4HDAC1HDAC2 | |
| SCHEMBL21224487 | 0.90 | HDAC4 (0.57) | CTSSCTSKHDAC4HDAC1HDAC2 | |
| SCHEMBL21224246 | 0.89 | HDAC4 (0.54) | HDAC4HDAC1HDAC2HDAC3HDAC7 | |
| SCHEMBL21224245 | 0.89 | HDAC4 (0.54) | HDAC4HDAC1HDAC2HDAC3HDAC7 | |
| SCHEMBL21224160 | 0.88 | HDAC4 (0.60) | CTSSCTSKHDAC4HDAC1HDAC2 | |
| SCHEMBL21224159 | 0.88 | HDAC4 (0.60) | CTSSCTSKHDAC4HDAC1HDAC2 | |
| SCHEMBL21225194 | 0.88 | SCN9A (0.54) | HDAC4HDAC1HDAC2HDAC3HDAC7 | |
| SCHEMBL21224256 | 0.88 | HDAC3 (0.54) | HDAC4HDAC1HDAC2HDAC3HDAC7 | |
| SCHEMBL21224257 | 0.88 | HDAC3 (0.54) | HDAC4HDAC1HDAC2HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2021-02-11 | — | — | US | disclosed |
| CN-112153984-A | Compound and use thereof | 福宏治疗公司 | 2020-12-29 | — | — | CN | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | CTSS 2010/4885CTSK 2434/4885HDAC4 152/4885 |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | CTSS 2010/4885CTSK 2434/4885HDAC4 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.