Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34471500 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAPDE10APAK4KDM4E | |
| SCHEMBL25260771 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAKDM4EMAPTMEN1 | |
| SCHEMBL31679132 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAKDM4EMAPTMEN1 | |
| SCHEMBL25239058 | 0.77 | SMN1; SMN2 (0.32) | SMN1; SMN2LMNAKDM4EMAPTMEN1 | |
| SCHEMBL25425575 | 0.73 | ALDH1A1 (0.32) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL25291277 | 0.73 | RECQL (0.34) | SMN1; SMN2 | |
| SCHEMBL35211618 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAPDE10APAK4ALDH1A1 | |
| SCHEMBL6664363 | 0.69 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAPDE10AKDM4EALDH1A1 | |
| SCHEMBL25739708 | 0.69 | MAPT (0.33) | SMN1; SMN2KDM4EMAPTPOLB | |
| SCHEMBL31389813 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAPDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070754-A1 | JAK INHIBITOR AND USE THEREOF | ZHUHAI UNITED LABORATORIES CO., LTD. (CN) | 2021-03-11 | — | — | US | disclosed |
| WO-2019149244-A1 | JAK INHIBITOR AND USE THEREOF | 南京明德新药研发股份有限公司 | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070754-A1 | JAK INHIBITOR AND USE THEREOF | JAK1, JAK2, TYK2 | SMN1; SMN2 3000/4885LMNA 4289/4885PDE10A 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.