Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211108 | 0.93 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL211144 | 0.87 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL211145 | 0.87 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL212428 | 0.87 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL211794 | 0.85 | ATR (0.39) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL210428 | 0.83 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL210430 | 0.83 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL209966 | 0.82 | CTSK (0.34) | RAB9AALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL212322 | 0.81 | MAPT (0.40) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL211087 | 0.81 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |