Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246351 | 1.00 | GRIN2B (0.43) | GRIN2BGRIN2CUSP19SMN1; SMN2LMNA | |
| SCHEMBL21246354 | 1.00 | GRIN2B (0.43) | GRIN2BGRIN2CUSP19SMN1; SMN2LMNA | |
| SCHEMBL21246333 | 0.87 | GRM5 (0.34) | GRIN2BGRIN2CUSP19SMN1; SMN2GRM5 | |
| SCHEMBL21246334 | 0.83 | USP19 (0.32) | GRIN2BGRIN2CUSP19GRM5 | |
| SCHEMBL21246335 | 0.83 | USP19 (0.32) | GRIN2BGRIN2CUSP19SMN1; SMN2GRM5 | |
| SCHEMBL21246349 | 0.80 | USP19 (0.33) | USP19GRM5 | |
| SCHEMBL21246360 | 0.79 | USP19 (0.32) | USP19 | |
| SCHEMBL19839437 | 0.77 | GRIN2B (0.50) | GRIN2BGRIN2C | |
| SCHEMBL19854377 | 0.77 | GRIN2B (0.50) | GRIN2BGRIN2C | |
| SCHEMBL19839438 | 0.77 | GRIN2B (0.50) | GRIN2BGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152688-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |