Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246349 | 0.89 | USP19 (0.33) | USP19 | |
| SCHEMBL21246334 | 0.85 | USP19 (0.32) | USP19 | |
| SCHEMBL21246427 | 0.82 | SLC1A2 (0.47) | USP19 | |
| SCHEMBL21246333 | 0.80 | GRM5 (0.34) | USP19 | |
| SCHEMBL21246426 | 0.80 | GAA (0.41) | POLBHSD11B1HPGD | |
| SCHEMBL21246354 | 0.79 | GRIN2B (0.43) | USP19 | |
| SCHEMBL21246351 | 0.79 | GRIN2B (0.43) | USP19 | |
| SCHEMBL21246352 | 0.79 | GRIN2B (0.43) | USP19 | |
| SCHEMBL21246359 | 0.79 | SLC1A2 (0.51) | HPGD | |
| SCHEMBL21246335 | 0.77 | USP19 (0.32) | USP19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152688-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |