Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22578934 | 0.93 | HTT (0.32) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL21246765 | 0.93 | HTT (0.32) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL22578883 | 0.92 | HTT (0.33) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL21246832 | 0.89 | LIPE (0.31) | HTTSMN1; SMN2 | |
| SCHEMBL26310727 | 0.89 | HTT (0.32) | HTTSMN1; SMN2 | |
| SCHEMBL22556080 | 0.84 | HTT (0.31) | HTTSMN1; SMN2 | |
| SCHEMBL22556130 | 0.83 | LIPE (0.33) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL21246757 | 0.83 | DGAT1 (0.34) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL29750684 | 0.83 | DGAT1 (0.34) | HTTSMN1; SMN2DGAT1 | |
| SCHEMBL22556109 | 0.82 | HTT (0.30) | HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749672-B1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RES OICR (CA) | 2022-07-27 | — | — | EP | disclosed |
| EP-3749672-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2020-12-16 | — | — | EP | disclosed |
| EP-3728267-A1 | TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2020-10-28 | — | — | EP | disclosed |
| WO-2019153080-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-08-15 | — | — | WO | disclosed |