Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 12/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246980 | 0.85 | AR (0.53) | AR | |
| SCHEMBL21246983 | 0.80 | P2RX3 (0.45) | NPC1RAB9ATDP1HDAC4HDAC6 | |
| SCHEMBL22667535 | 0.77 | IGF1R (0.51) | ARNPC1RAB9ATDP1PTGS1 | |
| SCHEMBL16831500 | 0.75 | NPC1 (0.57) | NPC1RAB9ATDP1MEN1KMT2A | |
| SCHEMBL29396501 | 0.75 | NPC1 (0.57) | NPC1RAB9ATDP1MEN1KMT2A | |
| SCHEMBL21261284 | 0.74 | IGF1R (0.36) | ARNPC1RAB9ATDP1PTGS1 | |
| Formic Acid SCHEMBL6366129 | 0.74 | IDO1 (0.53) | NPC1RAB9ATDP1HDAC4HDAC6 | |
| SCHEMBL22667564 | 0.72 | AR (0.50) | AR | |
| SCHEMBL21261251 | 0.72 | ESR1 (0.34) | ARNPC1RAB9ATDP1PTGS1 | |
| SCHEMBL21261255 | 0.72 | ALB (0.36) | ARNPC1RAB9ATDP1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11376228-B2 | Polysubstituted benzene, preparation method thereof, and method of using the same | GENIFARM LABORATORIES INC (CN) | 2022-07-05 | — | — | US | disclosed |
| CN-110143858-B | Polysubstituted benzene compound with bioactivity and preparation method and application thereof | 华南理工大学 | 2022-04-29 | — | — | CN | disclosed |
| EP-3753931-A1 | MULTI-SUBSTITUTED BENZENE COMPOUND HAVING BIOLOGICAL ACTIVITY, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Genifarm Laboratories Inc (CN) | 2020-12-23 | — | — | EP | disclosed |
| EP-3753931-A1 | MULTI-SUBSTITUTED BENZENE COMPOUND HAVING BIOLOGICAL ACTIVITY, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Genifarm Laboratories Inc (CN) | 2020-12-23 | — | — | EP | disclosed |
| US-20200361893-A1 | POLYSUBSTITUTED BENZENE, PREPARATION METHOD THEREOF, AND METHOD OF USING THE SAME | SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) | 2020-11-19 | — | — | US | disclosed |
| WO-2019153954-A1 | MULTI-SUBSTITUTED BENZENE COMPOUND HAVING BIOLOGICAL ACTIVITY, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 广州自远生物科技有限公司 | 2019-08-15 | — | — | WO | disclosed |
| WO-2019153954-A1 | MULTI-SUBSTITUTED BENZENE COMPOUND HAVING BIOLOGICAL ACTIVITY, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 广州自远生物科技有限公司 | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11376228-B2 | Polysubstituted benzene, preparation method thereof, and method of using the same | CBR1, CBR3, C1S | AR 842/4885NPC1 1693/4885RAB9A 3771/4885 |
| US-20200361893-A1 | POLYSUBSTITUTED BENZENE, PREPARATION METHOD THEREOF, AND METHOD OF USING THE SAME | CBR1, CBR3, C1S | AR 842/4885NPC1 1693/4885RAB9A 3771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.