Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | AGXT | P21549 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL28823289 | 0.87 | IDO1 (0.61) | IDO1AGXTCA1CA2HTT | |
| SCHEMBL34413 | 0.87 | IDO1 (0.67) | IDO1AGXTCA1CA2HTT | |
| Potassium SCHEMBL1477050 | 0.85 | IDO1 (0.64) | IDO1AGXTCA1CA2HTT | |
| Bromide SCHEMBL28558295 | 0.85 | IDO1 (0.64) | IDO1AGXTCA1CA2HTT | |
| Methoxymethane SCHEMBL28823290 | 0.85 | IDO1 (0.64) | IDO1AGXTCA1CA2HTT | |
| SCHEMBL1475481 | 0.85 | IDO1 (0.64) | IDO1AGXTCA1CA2HTT | |
| Hydrochloric Acid SCHEMBL28912134 | 0.85 | IDO1 (0.68) | IDO1AGXTCA1CA2HTT | |
| SCHEMBL19209511 | 0.85 | ALDH1A1 (0.70) | IDO1AGXTCA1CA2HTT | |
| SCHEMBL3961229 | 0.82 | IDO1 (0.52) | IDO1AGXTCA1CA2HTT | |
| SCHEMBL18320532 | 0.82 | IDO1 (0.55) | IDO1AGXTCA1CA2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861537-B2 | Tricyclic and tetracyclic taxane intermediates | FLORIDA STATE UNIVERSITY (US) | 2005-03-01 | — | — | US | disclosed |
| EP-0960881-B1 | Synthesis of taxol and its derivatives | UNIV FLORIDA STATE (US) | 2003-04-23 | — | — | EP | disclosed |
| US-20030050485-A1 | For the preparation of taxol and other tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY | 2003-03-13 | — | — | US | disclosed |
| US-6433189-B2 | Tricyclic and tetracyclic taxane intermediates | FLORIDA STATE UNIVERSITY | 2002-08-13 | — | — | US | disclosed |
| US-20010053857-A1 | Tricyclic and tetracyclic taxane intermediates | HOLTON ROBERT A (US) | 2001-12-20 | — | — | US | disclosed |
| US-6278026-B1 | USED IN SYNTHESIS OF TAXOL AND OTHER TRICYCLIC AND TETRACYCLIC TAXANES | FLORIDA STATE UNIVERSITY | 2001-08-21 | — | — | US | disclosed |
| EP-0710223-B1 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | UNIV FLORIDA STATE (US) | 2000-06-14 | — | — | EP | disclosed |
| US-6005120-A | INTERMEDIATE FOR USE IN THE PREPARATION OF TAXOL OR OTHER TRICYCLIC OR TETRACYCLIC TAXANES | FLORIDA STATE UNIVERSITY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0960881-A1 | Synthesis of taxol and its derivatives | FLORIDA STATE UNIVERSITY (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5760252-A | Synthetic process for the preparation of tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5637732-A | Tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5618952-A | Synthetic process for the preparation of tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1997-04-08 | — | — | US | disclosed |
| US-5405972-A | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1995-04-11 | — | — | US | disclosed |
| WO-1995003265-A1 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | FLORIDA STATE UNIVERSITY (US) | 1995-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053857-A1 | Tricyclic and tetracyclic taxane intermediates | TUBB, TYMS, TUBA1C | IDO1 4198/4885AGXT 1464/4885CA1 1875/4885 |
| US-20030050485-A1 | For the preparation of taxol and other tricyclic and tetracyclic taxanes | TUBA1C, TUBB, TUBA1A | IDO1 4791/4885AGXT 3350/4885CA1 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.