SCHEMBL21247044

SCHEMBL21247044

O=C(O)c1cccc(C(=O)c2ccc(F)cc2)c1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.55
CDC25B P30305 2/20 0.53
ATM Q13315 1/20 0.53
NR4A1 P22736 1/20 0.51
CDC25A P30304 1/20 0.49
HSD17B10 Q99714 1/20 0.49
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
HPGD P15428 1/20 0.46
ALOX12 P18054 1/20 0.46
BCL2L1 Q07817 1/20 0.46
BAD Q92934 1/20 0.46
MYC P01106 1/20 0.45
POLB P06746 1/20 0.44
ALB P02768 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL425272 0.91 AKR1C3 (0.65) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL503678 0.87 AKR1C3 (0.73) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL23501588 0.87 AKR1C3 (0.61) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL144047 0.85 AKR1C3 (0.76) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL30978151 0.85 AKR1C3 (0.76) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL5178136 0.85 NR4A1 (0.51) AKR1C3CDC25BATMNR4A1ALDH1A1
Benzene SCHEMBL28318261 0.85 AKR1C3 (0.61) AKR1C3CDC25BATMNR4A1CDC25A
Hydrochloric Acid SCHEMBL10626938 0.83 AKR1C3 (0.73) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL10480661 0.83 KDM4E (0.60) AKR1C3CDC25BATMHSD17B10KDM4E
SCHEMBL27873928 0.83 AKR1C3 (0.65) AKR1C3CDC25BATMNR4A1CDC25A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3750885-A1 COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2020-12-16 EP disclosed
EP-3750885-A1 COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2020-12-16 EP disclosed
CN-111683932-A Compound with BET inhibition activity, preparation method and application thereof 上海海和药物研究开发有限公司 2020-09-18 CN disclosed
WO-2019154329-A1 COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR 上海海和药物研究开发有限公司 2019-08-15 WO disclosed
WO-2019154329-A1 COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR 上海海和药物研究开发有限公司 2019-08-15 WO disclosed