Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MYC | P01106 | 2/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | FABP3 | P05413 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21248515 | 0.89 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL21248588 | 0.86 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL1688337 | 0.85 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL18667006 | 0.85 | HCAR3 (0.72) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL453183 | 0.84 | AKR1C3 (0.68) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2112961 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2646698 | 0.84 | AKR1C3 (0.71) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL29532900 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL23567 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL29377063 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749325-B1 | DREADD ACTUATORS | US HEALTH (US) | 2026-04-08 | — | — | EP | disclosed |
| US-11739063-B2 | DREADD actuators | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-08-29 | — | — | US | disclosed |
| US-20200399228-A1 | DREADD ACTUATORS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-12-24 | — | — | US | disclosed |
| EP-3749325-A1 | DREADD ACTUATORS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019157083-A1 | DREADD ACTUATORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739063-B2 | DREADD actuators | GRK1, GRK3, GRK2 | AKR1C3 1114/4885AKR1C2 1252/4885AKR1B1 897/4885 |
| US-20200399228-A1 | DREADD ACTUATORS | GRK1, GRK3, GRK2 | AKR1C3 1114/4885AKR1C2 1252/4885AKR1B1 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.