Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MYC | P01106 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.52 |
| ▸ | FABP3 | P05413 | 1/20 | 0.52 |
| ▸ | FABP4 | P15090 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688337 | 0.85 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL18667006 | 0.85 | HCAR3 (0.72) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2648507 | 0.84 | AKR1C3 (0.81) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2648512 | 0.84 | AKR1C3 (0.81) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL453183 | 0.84 | AKR1C3 (0.68) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL23567 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL29377063 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2112961 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL21248526 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL29532900 | 0.84 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057088-C | Benzimidazole compounds, their use and preparation | NEUROSEARCH AS (DK) | 2000-10-04 | — | — | CN | disclosed |
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| CN-1099391-A | Benzimidazole compounds, their use and preparation | NEUROSEARCH AS (JP) | 1995-03-01 | — | — | CN | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |