Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15898105 | 0.93 | SYK (0.49) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL16096742 | 0.91 | CTSL (0.52) | SYKCTSLKMT2A | |
| SCHEMBL21062628 | 0.89 | GPR119 (0.56) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL22552461 | 0.89 | GPR119 (0.56) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL22552460 | 0.89 | GPR119 (0.56) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL29940905 | 0.86 | SYK (0.54) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL29584585 | 0.85 | SYK (0.51) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL29290615 | 0.85 | SYK (0.51) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL30704974 | 0.85 | SYK (0.51) | SYKBACE1CTSLP2RX7GPR119 | |
| SCHEMBL29290594 | 0.85 | GPR119 (0.48) | SYKBACE1CTSLP2RX7GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752498-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019157458-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2019-08-15 | — | — | WO | disclosed |