Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140246 | 0.76 | EGLN1 (0.58) | EGLN1KDM4EEGFRUSP30HDAC3 | |
| Iodide SCHEMBL5956032 | 0.76 | PABPC1 (0.53) | PABPC1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL12680191 | 0.75 | EGLN1 (0.50) | EGLN1KDM4EKMT2AMEN1EGFR | |
| Iodide SCHEMBL31327468 | 0.75 | LMNA (0.52) | PABPC1KDM4EKMT2AMEN1RAB9A | |
| Iodide SCHEMBL1930231 | 0.75 | LMNA (0.52) | PABPC1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL20646994 | 0.74 | EGLN1 (0.49) | EGLN1EGFRUSP30HDAC3HDAC1 | |
| SCHEMBL6169104 | 0.74 | PTPN1 (0.51) | EGLN1EGFRUSP30HDAC3HDAC1 | |
| Iodide SCHEMBL15363594 | 0.74 | KDM4E (0.59) | PABPC1KDM4EKMT2AMEN1HDAC1 | |
| SCHEMBL155043 | 0.73 | EGLN1 (0.54) | EGLN1KDM4EKMT2AMEN1EGFR | |
| SCHEMBL29746814 | 0.73 | EGLN1 (0.54) | EGLN1KDM4EKMT2AMEN1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105576138-B | Platinum (II) isoquinoline-pyridine-benzene-based complex, preparation method thereof and organic light emitting diode prepared therefrom | 港大科桥有限公司 | 2020-12-25 | — | — | CN | disclosed |
| EP-2443132-B1 | PLATINUM (II) ISOQUINOLINE-PYRIDINE-BENZENE BASED COMPLEXES, PREPARING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DIODES MADE THEREFROM | VERSITECH LTD (CN) | 2018-10-10 | — | — | EP | disclosed |
| US-9023490-B2 | Extended pi-conjugated platinum (II) complexes | VERSITECH LIMITED (CN) | 2015-05-05 | — | — | US | disclosed |
| EP-2443132-A1 | PLATINUM (II) ISOQUINOLINE-PYRIDINE-BENZENE BASED COMPLEXES, PREPARING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DIODES MADE THEREFROM | Versitech Limited (CN) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145190-A1 | PLATINUM (II) ISOQUINOLINE-PYRIDINE-BENZENE BASED COMPLEXES, PREPARING METHOD THEREOF, AND ORGANIC LIGHT-EMITTING DIODES MADE THEREFROM | THE UNIVERSITY OF HONG KONG (CN) | 2010-12-23 | — | — | WO | disclosed |
| US-20100314994-A1 | Platinum (II) Isoqulinoline-Pyridine-Benzene Based Complexes, Methods for Making Same, and Organic Light-Emitting Diodes Including Such Complexes | VERSITECH LIMITED (CN) | 2010-12-16 | — | — | US | disclosed |
| US-20080309227-A1 | EXTENDED PI-CONJUGATED PLATINUM (II) COMPLEXES | VERSITECH LIMITED (CN) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100314994-A1 | Platinum (II) Isoqulinoline-Pyridine-Benzene Based Complexes, Methods for Making Same, and Organic Light-Emitting Diodes Including Such Complexes | OCIAD2, PDCD1LG2, PDCD2L | EGLN1 4822/4885PABPC1 4745/4885KDM4E 2906/4885 |
| US-20080309227-A1 | EXTENDED PI-CONJUGATED PLATINUM (II) COMPLEXES | LIG4, PARG, PARN | EGLN1 4877/4885PABPC1 1396/4885KDM4E 3714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.