Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240312 | 0.92 | TTK (0.37) | TTKPIM1PIM3PIM2MAP4K4 | |
| SCHEMBL29578336 | 0.92 | TTK (0.37) | TTKPIM1PIM3PIM2MAP4K4 | |
| SCHEMBL21251736 | 0.89 | TTK (0.35) | TTK | |
| SCHEMBL24488209 | 0.88 | TTK (0.37) | TTKMAP4K4MAOBHTR6LRRK2 | |
| SCHEMBL20331964 | 0.87 | PDE10A (0.36) | TTK | |
| SCHEMBL29578107 | 0.87 | PDE10A (0.36) | TTK | |
| SCHEMBL29577692 | 0.83 | TTK (0.36) | TTK | |
| SCHEMBL20331104 | 0.83 | TTK (0.36) | TTK | |
| SCHEMBL20331101 | 0.82 | MEN1 (0.36) | — | |
| SCHEMBL21240243 | 0.82 | TTK (0.38) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |