Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331754 | 0.91 | FGFR4 (0.33) | TTKFGFR4 | |
| SCHEMBL30045025 | 0.91 | FGFR4 (0.33) | TTKFGFR4 | |
| SCHEMBL30442688 | 0.87 | TTK (0.34) | TTKFGFR4 | |
| SCHEMBL30045165 | 0.85 | TTK (0.33) | TTKFGFR4 | |
| SCHEMBL20331960 | 0.85 | TTK (0.33) | TTKFGFR4 | |
| SCHEMBL20331784 | 0.83 | TTK (0.36) | TTKFGFR4 | |
| SCHEMBL30046092 | 0.83 | TTK (0.36) | TTKFGFR4 | |
| SCHEMBL21240493 | 0.83 | TTK (0.38) | TTKFGFR4 | |
| SCHEMBL29578139 | 0.83 | TTK (0.38) | TTKFGFR4 | |
| SCHEMBL30442682 | 0.83 | NOS1 (0.36) | TTKFGFR4MEN1KMT2ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |